Compact/Condensed DNA in Stem Cells

(This discussion will be added next month - Jan 2018 - below are a few preview thoughts and sketches.)

Without the physics play-by-play, let us simply look at what the Guanine-Cytosine pairing structure would look like after a coordinated tunneling event involving the linking H-bonds ...

Compact DNA

The contracted/condensed/crimped G-C structure is shown at the top; the Watson-Crick structure at the bottom. To make sense of these images you have to pay attention to the atomic mass numbers adjacent to each atom. But, look at the resonance energy advantages at the core for the electrons set free from their double=bonds. Further, look too at the stacking advantages.

There is no direct evidence for this crimped >DNA< structure any more than there is for Watson-Crick – but, if you were looking for stability in a foundational molecule, which structure would you choose?

Crimped DNA

By such thinking, the W-C DNA model is imagined to be an excited state of the more stable low energy state of >DNA<. The wobbled W-C structure is what we find when DNA is removed from the pressure and stabilizing mechanisms of the cell environs. Arguments can be offered for >DNA< being the undifferentiated state in stem cells. This form also provides fascinating modeling opportunities to link DNA with proteins and other functional molecules in the cytosol.

Compact G-C